• صفحه اصلی
  • مرور
    • شماره جاری
    • بر اساس شماره‌های نشریه
    • بر اساس نویسندگان
    • بر اساس موضوعات
    • نمایه نویسندگان
    • نمایه کلیدواژه ها
  • اطلاعات نشریه
    • درباره نشریه
    • اهداف و چشم انداز
    • اعضای هیات تحریریه
    • همکاران دفتر نشریه
    • اصول اخلاقی انتشار مقاله
    • بانک ها و نمایه نامه ها
    • پیوندهای مفید
    • پرسش‌های متداول
    • فرایند پذیرش مقالات
    • اخبار و اعلانات
  • راهنمای نویسندگان
  • ارسال مقاله
  • داوران
  • تماس با ما
 
  • ورود به سامانه ▼
    • ورود به سامانه
    • ثبت نام در سامانه
  • English
صفحه اصلی فهرست مقالات مشخصات مقاله
  • ذخیره رکوردها
  • |
  • نسخه قابل چاپ
  • |
  • توصیه به دوستان
  • |
  • ارجاع به این مقاله ارجاع به مقاله
    RIS EndNote BibTeX APA MLA Harvard Vancouver
  • |
  • اشتراک گذاری اشتراک گذاری
    CiteULike Mendeley Facebook Google LinkedIn Twitter Telegram
مجله علمی-پژوهشی رایانش نرم و فناوری اطلاعات
مقالات آماده انتشار
شماره جاری
شماره‌های پیشین نشریه
دوره دوره 6 (1396)
دوره دوره 5 (1395)
شماره شماره 4
شماره شماره 3
شماره شماره 2
شماره شماره 1
دوره دوره 4 (1394)
دوره دوره 3 (1393)
Farajzadeh, Mohammad Ghasem, Tayarany, Ali, Hosseini Sani, Seyed Kamal. (1396). An Efficient Method for Controlling of CML Treatment System. مجله علمی-پژوهشی رایانش نرم و فناوری اطلاعات, 5(1), 53-61.
Mohammad Ghasem Farajzadeh; Ali Tayarany; Seyed Kamal Hosseini Sani. "An Efficient Method for Controlling of CML Treatment System". مجله علمی-پژوهشی رایانش نرم و فناوری اطلاعات, 5, 1, 1396, 53-61.
Farajzadeh, Mohammad Ghasem, Tayarany, Ali, Hosseini Sani, Seyed Kamal. (1396). 'An Efficient Method for Controlling of CML Treatment System', مجله علمی-پژوهشی رایانش نرم و فناوری اطلاعات, 5(1), pp. 53-61.
Farajzadeh, Mohammad Ghasem, Tayarany, Ali, Hosseini Sani, Seyed Kamal. An Efficient Method for Controlling of CML Treatment System. مجله علمی-پژوهشی رایانش نرم و فناوری اطلاعات, 1396; 5(1): 53-61.

An Efficient Method for Controlling of CML Treatment System

مقاله 6، دوره 5، شماره 1، بهار 1395، صفحه 53-61  XML اصل مقاله (1222 K)
نویسندگان
Mohammad Ghasem Farajzadeh 1؛ Ali Tayarany1؛ Seyed Kamal Hosseini Sani2
1M.S. Student, Department of Electrical Engineering, Ferdowsi University of Mashhad, Mashhad, Iran
2Assistant Professor, Department of Electrical Engineering, Ferdowsi University of Mashhad, Mashhad, Iran
چکیده
Chronic myelogenous leukemia (CML) is a kind of blood cancer, which produces abnormal white blood cells uncontrollably. Modeling of this type of disease can help for treatment of it to physicians. In this paper we proposed an efficient method for CML treatment. In this method, a nonlinear multivariable system is considered as the plant of the CML treatment. Then an efficient centralized multi-input multi-output proportional and integral (CMIMOPI) controller is proposed for this system. Results show that proposed CMIMOPI controller can control CML disease well, by using low dosage of drugs. Although the real plant is nonlinear, however the controller has good robustness and can stabilize the system for various conditions. Simulation results show that the steady state population of cancer cells at the end of treatment period is highly reduced and the rate of cancer improvement is independent from reproduction of cancer cells.
کلیدواژه‌ها
Chronic Myelogenous Leukemia (CML) treatment؛ Disease Modelling؛ MIMO system؛ Centralized controller؛ PI controller
مراجع

[1]     H. Moore and N. K, LI., "A mathematical model for chronic myelogenous leukemia (CML) and T cell interaction," Theoretical Biology vol. 227, pp. 513-523, 2004.

[2]     R. Padhi and M. Kothari, "An optimal dynamic inversion-based neuro-adaptive approach for treatment of chronic myelogenous leukemia," computer methods and programs in biomedicine, vol. 87, pp. 208-224, 2007.

[3]     Paula, Chronic Myeloid Leukemia Booklet: The Leukemia & Lymphoma Society, revised in 2012.

[4]     C. V. Cotta and C. E. Bueso-Ramos, "New insights into the pathobiology and treatment of chronic myelogenous leukemia," Annals of Diagnostic Pathology vol. 11, pp. 68, 2007.

[5]     M. Baccarani and et.al., " Imatinib and pegylated human recombinant interferon-alpha2b in early chronic-phase chronic myeloid leukemia," The American Society of Hematology, vol. Blood 104  (13), pp. 4245-4251, 2004.

[6]     T. Thiesing and et.al., ", Efficacy of STI571, an Abl tyrosine kinase inhibitor, in conjunction with other antileukemic agents against Bcr-Ablpositive cells," The American Society of Hematology, vol. Blood 96 pp. 3195-3199, 2000.

[7]     "The Scott Hamilton CARES Initiative," http://www.chemocare.com/bio/cytarabine.asp, 17.9.2012.

[8]     S. P. Chakrabarty and F. B. Hanson, "Optimal control of drug delivery to brain tumors for a distributed parameters model," presented at Proceedings of the American Control Conference 2005.

[9]     K. R. Fister and J. C. Panetta, "Optimal control applied to cell-cycle-specific cancer chemotherapy," SIAM J. Appl.Math, vol. 60, pp. 1059-1072, 2000.

[10]   U. Ledzewicz and H. Schattler, "Analysis of a cell cycle specific model for cancer chemotherapy," Biol. Syst, vol. 10, pp. 183, 2002.

[11]   Thomas-Schoemann, Audrey, and e. al., "Drug interactions with solid tumour-targeted therapies," Critical Reviews in Oncology/Hematology, vol. 89, pp. 179-196, 2013.

[12]   Oliveira, Sabrina, and e. al., "Targeting tumors with nanobodies for cancer imaging and therapy," Journal of Controlled Release, vol. 172, pp. 607-617, 2013.

[13]   Yin, Qi, and e. al., "Reversal of multidrug resistance by stimuli-responsive drug delivery systems for therapy of tumor," Advanced drug delivery reviews, vol. 65, pp. 1699-1715, 2013.

[14]   K. Takara, et al., "Size-controlled, dual-ligand modified liposomes that target the tumor vasculature show promise for use in drug-resistant cancer therapy," Journal of Controlled Release, vol. 162, pp. 225-232, 2012.

[15]   M. C. Mackey and L. Pujo-Menjouet, "Contribution to the study of periodic chronic myelogenous leukemia," C. R. Biol. 327 vol. 3, pp. 235-244, 2004.

[16]   F. Michor and et.al., "Dynamics of chronic myeloid leukemia," Nature vol. 435, pp. 1267-1270, 2005.

[17]   S. Nanda, H. Moore, and S. Lenhart, "Optimal control of treatment in a mathematical model of chronic myelogenous Leukemia," Mathematical Biosciences vol. 210, pp. 143-156, 2007.

[18]   B. Aïnseba and C. Benosman, "Optimal control for resistance and suboptimal response in CML," Mathematical Biosciences, vol. 227, pp. 81–93, 2010.

[19]   R. Borrelli and C. Coleman, Differential Equations: A Modeling Perspective. New York: Wiley, 1998.

[20]   J. M. Maciejowski, Multivariable Feedback Design: Addison – Wesley, 1989.

[21]   M. Green and D. N. Limebeer, Linear robust control: Prentice – Hall, 1995.

[22]   A. Khaki Sedigh, Analysis and Design of Multivariable Control Systems. Tehran: Khajenasir, 2010.

[23]   S. Skogestad and I. Postlethwaite, Multivariable Feedback Control Analysis and Design, Second ed: Wiley, 2005.

[24]   Q. G. Wang, C. Ye, N. Jaci, and C. C. Hang, "PID Control for Multivariable Processes," LNCIS, Springer Verlag, 2008.

[25]   D. H. Owens, "Feedback and Multivariable Systems," IEEE Control engineering series, 1978.

[26]   R. V. Patel, Multivariable System Theory and Design: Pergamon press, 1982.

[27]   V. V. Kulkarni, M. V. Kothare, and M. G. Safonov, "Decentralized dynamic nonlinear controllers to minimize transmit power in cellular networks, Part I," Systems & Control Letters, 2010.

آمار
تعداد مشاهده مقاله: 71
تعداد دریافت فایل اصل مقاله: 34
صفحه اصلی | واژه نامه اختصاصی | اخبار و اعلانات | اهداف و چشم انداز | نقشه سایت
ابتدای صفحه ابتدای صفحه

Journal Management System. Designed by sinaweb.