An Efficient Method for Controlling of CML Treatment System


1 M.S. Student, Department of Electrical Engineering, Ferdowsi University of Mashhad, Mashhad, Iran

2 Assistant Professor, Department of Electrical Engineering, Ferdowsi University of Mashhad, Mashhad, Iran


Chronic myelogenous leukemia (CML) is a kind of blood cancer, which produces abnormal white blood cells uncontrollably. Modeling of this type of disease can help for treatment of it to physicians. In this paper we proposed an efficient method for CML treatment. In this method, a nonlinear multivariable system is considered as the plant of the CML treatment. Then an efficient centralized multi-input multi-output proportional and integral (CMIMOPI) controller is proposed for this system. Results show that proposed CMIMOPI controller can control CML disease well, by using low dosage of drugs. Although the real plant is nonlinear, however the controller has good robustness and can stabilize the system for various conditions. Simulation results show that the steady state population of cancer cells at the end of treatment period is highly reduced and the rate of cancer improvement is independent from reproduction of cancer cells.


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